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Timi iii flow4/6/2023 This cross-sectional study included 110 patients aged 18 to 82 years visiting the emergency department of the National Institute of Cardiovascular Diseases, Karachi, Pakistan, from August 2015 to March 2016. This study has been performed to find the rate of MVD and subsequent TIMI flow grade III in patients who have undergone primary PCI. Post-procedure TIMI flow grade III was found to be linked with decreased chances of death and morbidity, lower enzyme peaks, and improved global outcomes, including regional left ventricular function. TIMI flow grade II or III of the native artery after a primary percutaneous coronary intervention (PCI) is indicative of the procedure success. The thrombolysis in myocardial infarction (TIMI) flow grade assessment is the standard criterion for the evaluation of coronary reperfusion yield. CAD involving multiple vessels has been linked to increased chances of mortality and morbidity amongst patients suffering from the disease. Īccording to multiple studies involving clinical trials and institutional registries, multivessel CAD (MVD) was documented in around half of the patients with acute myocardial infarction (AMI). The high rates of CAD in the South Asian population have been linked to an ongoing epidemiological transition and a higher prevalence of cardiac risk factors, such as hypertension (HTN), obesity, sedentary lifestyle, smoking, and type II diabetes mellitus (DM), in the region. This has resulted in a spike of coronary artery disease (CAD) occurrence, and therefore it becomes essential to study, analyse, and understand which internal and external factors cause a high risk of disease so that strategies to prevent the disease may be developed. Due to the fast growth of cities in this part of the world, more people have moved to urban centers. The populations of South Asian countries are at the highest risk of developing the CVD therefore, they experience the highest rates of death across the world. Nearly 80% of this global burden consists of low- and middle-income populations. In 2017, CVDs claimed 17.8 million lives and 35.6 million years of life lost due to disabilities. Globally, cardiovascular diseases (CVDs) claim the highest number of lives and significantly contribute to poor quality of life each year. It can be concluded that primary PCI has a significant role in the early restoration of myocardial blood flow following STEMI regardless of the vessels involved. Post-procedure TIMI flow grade III was accomplished in almost 90% of the subjects with or without MVD. Ninety percent (n=99) of the patients exhibited TIMI flow grade III after the procedure with no significant difference between patients with MVD and those with single-vessel disease with a rate of 87.3% (n=48/55) versus 92.7% (n=51/55, P=0.527), respectively. Coronary angiography showed MVD in 50.0% (n=55) of the patients, of whom 34 patients had two-vessel disease, and the remaining 21 had three-vessel disease. The proportion of male patients was 81.8% (n=90), and hypertension was the most prevalent risk factor followed by type II diabetes with a frequency of 67.3% (n=74) and 40.0% (n=44), respectively. The average age of the study sample was 56.3 ± 11.4 years. Pre-procedure angiographic findings regarding the number of vessels involved and post-procedure TIMI flow grade were assessed and analysed. All patients were diagnosed as ST-segment elevation myocardial infarction (STEMI) and had gone through primary PCI. This transverse study was carried out involving 110 patients from the emergency department of the National Institute of Cardiovascular Diseases, Karachi, Pakistan, from August 2015 to March 2016. This study has been performed to find the rate of multivessel CAD (MVD) and subsequent thrombolysis in myocardial infarction (TIMI) flow grade III in patients undergoing primary percutaneous coronary intervention (PCI). In underdeveloped countries, coronary artery disease (CAD) has developed into a serious health issue due to the high rates of risk factors such as obesity and smoking amongst the population.
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